Differential Hyperphosphorylation of Tau-S199, -T231 and -S396 in Organotypic Brain Slices of Alzheimer Mice. A Model to Study Early Tau Hyperphosphorylation Using Okadaic Acid
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چکیده
منابع مشابه
Hyperphosphorylation-Induced Tau Oligomers
In normal adult brain the microtubule associated protein (MAP) tau contains 2-3 phosphates per mol of the protein and at this level of phosphorylation it is a soluble cytosolic protein. The normal brain tau interacts with tubulin and promotes its assembly into microtubules and stabilizes these fibrils. In Alzheimer disease (AD) brain tau is three to fourfold hyperphosphorylated. The abnormally ...
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ژورنال
عنوان ژورنال: Frontiers in Aging Neuroscience
سال: 2018
ISSN: 1663-4365
DOI: 10.3389/fnagi.2018.00113